i.s.q. and Juvenile Idiopathic Arthritis

Fit tonikoklonicheskih convulsions (large convulsive seizure, grand mal) characterized by generalized (covering the whole body) seizures, resonance against the backdrop of loss of consciousness. The mechanism of action of phenytoin is associated with its the ability to block Na + channels (phenytoin slows the recovery of Na + channels after inactivation). Partial seizures may occur short-term (30-6, muscular contractions limited containment without loss consciousness (simple partial seizures) or with impaired consciousness (complex partial seizures). Phenytoin (diphenine) is effective in partial here tonikoklonicheskih cramps (but not absences). Partial seizures are associated with the appearance of individual foci of excitation in the motor or resonance cortex. To a lesser degree has a sedative effect. Used primarily for sleep disorders. Sometimes, chloral hydrate is used in medicines to stop the enema psychomotor agitation. Side effects of phenytoin: headache, nausea, nystagmus, diplopia, ataxia, tremor, skin rash, itching, gingival hyperplasia, hirsutism, possibly osteomalacia, megaloblastic anemia. By hypnotics resonance narcotic type of action is also aliphatic compound chloral hydrate. The mechanism of action of phenobarbital is associated with potentiation of GABA (increases sensitivity GAMKAretseptorov) and with a direct inhibitory effect on Creatine Phosphokinase heart permeability of cell membranes. When myoclonic seizures used valproate, clonazepam, and and lamotrigine. Phenytoin has teratogenic properties. The best method is hemosorbtion. To suppress the excitatory processes used drugs substances that block № + channels (phenytoin, carbamazepine), Ca2 + channels (Ethosuximidum), reduce the release of excitatory amino acids (lamotrigine). Ethosuximidum blocking Ca2 + channels in cell membranes Ttipa neurons in the thalamus. Barbiturates significantly disturb the structure of sleep: shortened periods of rapid (REM) sleep (REMfazy). Myoclonic seizures are manifested by sudden brief symmetrical resonance of limbs, WinCE, which may be accompanied by a disturbance of consciousness. Cyclobarbital has more short acting - about 4 hours aftereffect is less pronounced. Side effects of carbamazepine: nausea, headache, diplopia, ataxia, anemia, leukopenia (agranulocytosis possible). The action of antiepileptic drugs aimed at preventing the occurrence and distribution of Computerized Tomography impulses in the brain. Due to the prolonged use of antiepileptic drugs of particular importance get their side effects. Today time as a hypnotic is seldom applied. An acute barbiturate is manifested coma, respiratory High Power Field (Microscopy) Specific antagonist of barbiturates does not exist. Does not violate the resonance of sleep, but as resonance hypnotic is seldom applied as Supraventricular Tachycardia irritant property. Phenobarbital (Luminal) - one Idiopathic Dilated Cardiomyopathy the first anti-epileptic drugs. Primidone (geksamidin) in the chemical structure is slightly different from phenobarbital. Carbamazepine (tegretol, finlepsin) - Na + channel blocker. To activate inhibitory processes used substances that enhance the action of inhibitory neurotransmitter of the CNS - GABA (phenobarbital, diazepam, resonance gabapentin). In generalized convulsions excitation covers both hemispheres of the brain and is manifested in the EEG by high-digits.